Tattooer, Yes, the Red/Orange Misfit is a weaker overall ball compared to the other 3 misfits. The Red/Orange Misfit will get down the lane farther and is made for drier lanes. If you are looking for a good 1-2 punch of pin down and pin up, then I would suggest drilling a dude with a pin down and a diva pearl with a pin up. The diva pearl would give you that skid through the front part of the lane with more hook in the back end and allow you to moved deeper and throw it to the friction. I think that a pin up dude might be too smooth for what you are looking to do to create an arsenal.
To the original topic, The Dude and Melee have similar smooth reactions. The only difference that I have seen is that the Dude is slightly more angular. Both can handle medium oil to light oil conditions and don't over react when reaching friction. The Red/Orange Misfit was made for when the lanes are burning up and you need a weaker reacting ball to get through the front part of the lane but still has enough energy to get through the pins.