All of it really depends on the surface you're bowling on. Most lanes will eventually take your ball down to 600-800 grit. In charlee323's case, it probably depends on how oily the lanes are. If you throw a dull ball, no matter how finely sanded, always clean your balls right after bowling. Everyone has a favorite cleaner, but Simple Green works well and is cheap. It's easier to maintain the surface than try to get it back once it's been altered. If you really like it at 2000, it probably wouldn't hurt to hit it with some 2000 after every other set, especially if you have your own spinner. If you keep up with it, you probably won't even need the lower grits.
It would be nice if people would make their own posts instead of hijacking someone else's.
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Resurfacing depends on what you bowl on. On well maintained synthetics, it might be 6 months. On old, poorly maintained wood, it might be two weeks. Start with a new ball or one freshly resurfaced, then keep track of the time or number of games bowled and determine when the ball's reaction has changed significantly or the ball has a bunch of scratches on the track.
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Penn State ProudRon Clifton's Bowling Tip Archive