Well one example I can give right off the bat was with my Radical Fix.  Since I already owned a More Cash that I drilled max flare, max int diff pin up I needed a smoother oiler (that I could also use on house shot) so in that case and especially with that ball going pin down reduced the diff (and actually made the ball symmetric, pin up makes it an asym, Mo Pinel black magic) and made the ball smoother but the strong cover stock could still handle a puddle.  That layout also had a 5.5" pin to pap (35 x 5 ½" x 75 CG 1 ¼" pos. of Grip Center Balance Hole at PAP ).  So sometimes you may want to go both with a strong cover stock but admittedly that shape shifter core is not your usual ball.

Don’t get too wrapped around the axle with layouts, it just isn’t all that important in the grand scheme of things. Keep it simple with a few layouts that work well for you and try to matchup covers to the condition you’re bowling on.

Thanks for the reply. Pin down on a longer pin to pap would be different further. So what does this layout do ?

+1 on not sweating layouts too much.  Honestly for my style layout difference disappear in the noise of surface changes, oil transition, bowler inconsistency, etc.  Still to see for yourself what a smoother pin down long pin to pap lower diff symmetric looks like compared to a pin up, max flare (diff) shorter pin to pap, much sharper layout (basically becomes an asym ball) watch the following video.  Please keep in mind this ball (and this video, human bowler would probably not see as great a differences) are specifically designed to maximize the difference and even then its not as great as one would think.

Pin Up 60 x 3 ¾" x 30 CG 1 ¼" pos. of Grip Center, Balance Hole on VAL 1 ½" below PAP 
vs
Pin Down 35 x 5 ½" x 75 CG 1 ¼" pos. of Grip Center, Balance Hole at PAP

https://youtu.be/3CXht9MA51E