My PAP is 5 inches over and 1/2 inch up.  Rev Rate = 425.  Speed = 16 mph off the hand (right-handed).

Let's pretend I have 3 identical, symmetrical bowling balls OOB.
Let's pretend I decide to place a different layout on each (see below):

Ball 1 Layout: pin placed 3/4" under bridge, CG kicked 1/2" to right
Ball 2 Layout: pin placed 3/4" under ring finger, CG stacked beneath pin
Ball 3 Layout: pin placed 3/4" under ring finger, CG kicked 1" to right + P2 hole

What would be the difference in ball motion (shape) between the 3 balls on a pattern such as High Street (https://www.tenpinbowling.ie/Kegel%20Recreation%20Series%20%20HIGH%20STREET%20%208144.pdf)?

You won't see the difference between 1 and 2, and 3 will give you a slightly earlier roll with maybe a tad more flare separation.

But yeah, overthinking the layout.

Your rev rate is high enough you may see a couple of boards with your feet difference between 1 & 3 with 2 trying to squeeze between them. 

From my experience if you want to drill 2 of the same ball to be able to change balls to change carry drill them with about 1 1/2 inch difference in pin to PAP.