Every Asymetrical ball is shapped different, and when one is released, the manufacurer usually conducts classes on how to layout and drill the ball for specific bowler types. This is why you have to read the drilling instructions.
I have found over the years that people with a 45 degree release tend to get the manufacturer's intended reactions from the drilling instructions. If you get more than 45 degrees of rotation on the ball, let's say 75 degrees, you subtract 75 from 90 and get 15 degrees, and for a bowler that gets 75 degrees of axis rotation, that is the same as a 45 degree drilling for a 45 degree release. So if you want a 45 degree drilling and you get 75 degrees of axis rotation you should drill the mb at 15 degrees (90-75=15) from your pap.
If the drilling instructions say to drill a certain reaction at 90 degrees, you subtract 30 degrees (45-15) from 90 and drill the ball with the mass bias 60 degrees from the pap. If you want measurments, 3/8" = 5 degrees so if you want to drill the ball at 60 degrees you devide 60 by 5 = 12 x 3/8 = 36/8 = 4 2/8 or 4 1/4" from your pap.