On symmetric balls, the CG-no-matter stance on layouts is pin placement then weight hole placement, size, and depth. The CG is used to affect side weight to require a weight hole.
On an asymmetric ball with a marked mass bias, it's pin placement, MB placement, then weight hole. It may be that your MB placement doesn't require a weight hole on one ball but does on another due to the CG being in or out of line with the pin-MB.
Frankly, if it's truly about the weight hole and not the static weights, put the CG in grip center on every ball and still use the weight hole. If you end up with negative side weight, finger weight, or thumb weight, so what? What's the point in swinging the CG if static weights don't matter? Put it in the grip center and drill the weight hole anyway. But does anyone do that?
SH