A lot of it depends on how much topweight is in the ball to begin with, and how you feel about weight holes.
1. Yes, the location of the CG can impact the location of the weight hole. Probably will.
2. In general, a CG out to the left is better for a righty. Easier strong psa placement.
3. MAYBE, and I am inclined to initially say yes. Topweight will tell the tale on this one.
The CG being almost an inch left to start with means you are starting with instant side weight, and depending on how much you have, can dictate where to put the weighthole to make the ball "legal".
Then, when you shift it even further by putting the psa out at a 30-40 degree angle, you are going to end up with even more side weight.
IF THE BALL STARTS WITH LOW TOPWEIGHT, it will have less effect on the weighthole placement. If it has 3-4oz topweight, things might get problematic.
I'm going to assume that you understand that CG placement, especially on an asymmetric ball, is said to have much less effect than the psa placement. HOWEVER, the weighthole placement can have a big effect on overall post drilling spec numbers.
If you're a lefty, and you like strong psa placement, I would recommend using a ball that is either CG in line, or shifted to the right.
Not saying it can't be done, but it might be very hard with those specs if it is possible, and you don't need to make it any harder than it has to be.
