SSQ,
I don't think your idea will work.
Take the Zone asymmetric cores, for example. The locator pin marks the PSA, which can be described as a mass bias, meaning that the ball is biased toward spinning around that axis by the mass of the core. The locator pin on a Zone ball marks the spin axis that has the highest rg, which is the axis that has the most leverage working against any spin on that axis. Generally speaking, the mass creating the leverage is located 90 degrees from the locator pin. Therefore, if you drill a hole 90 degrees from the locator pin, then you will likely decrease the mass bias by removing some of the mass that makes the PSA the highest rg spin axis in the ball. In other words, by drilling 90 degrees from the locator pin, you will decrease the rg of the PSA, decreasing the mass bias.
By this logic, if you wanted to enhance the mass bias, then you would drill into the locator pin, which would further increase the rg of the PSA.
CK