I would say to lay the ball out as you normally would (pin distance, mb distance, and pin height) and then weight it prior to drilling. Providing that you can get the statics legal with deeper fingers and/or a weight hole, then go for it. I wouldn't worry about drilling into the cg...
S^2
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"The haddock hits me with a sucker punch. I catch him with a left hook.
He eels over. It was a fluke, but there he was, lying on the deck,
flat as a mackerel, kelpless."