If you are after control, the emphasis would be on your second layout of 50x4x70. There is a question though.
-Does the Hy-road Pearl have an X-Hole? You could essentially do the same layout and adjust the weight hole accordingly to give you more control then fine tune with surface.
Understand, the Marvel Pearl with a bigger block and lower RG not to mention stronger cover, will be earlier and smoother overall than Hy-Road Pearl. If you just drill it the same, it will be a ball up.