It all depends on where the marked MB ends up when you lay it out. Larger drill angles can push the MB into the thumb, and if the CG is out of line to the left, it could end up well left of centerline. And if it has enough top weight, you could be pushing it on negative side weight. This gets more noticeable as the horizontal distance for an axis point gets shorter, as even middle of the road drill angles can get the MB close to or into the thumb, and a long pin could end up well left of centerline. Just something to pay attention to.