Generally speaking, I'm assuming you mean a lable leverage with th pin over and maybe to the right of the ring finger vs. pin under the ring either stacked leverage or with a CG out.
If I'm correct in my assumptions in that scenario, the label leverage with the higher pin will go longer down the lane, with less midlane roll and possibly more backend if the lane is drier and/or the oil is shorter.
On an oilier lane, the pin under the ring (lower pin) will hook more on the backend, because the label leverage will go too long before it hooks.
The CG out will roll slightly smoother than the stack layout.
I would drill the ball with the pin under the ring with a slight Cg out, maybe an inch at the most. You can't really go wrong with this layout, unless you're a full roller or a spinner. =:^D
