Whats your favorite type of layout?  

These are my favorites:

pin below ring 4.5" to pap, 3.5" to 4" cg, no x-hole.

pin above ring 5" to pap, 3.5" to 4" cg, no x-hole.

label layout

I'm finding that not using x-holes really works well for me.  I still have a couple of balls that have them.  My angular has the pin below the ring and the cg kicked right to 2oz then brought back to 1oz with the x-hole below my pap.  The ball was too strong in the backend(flipped too hard) so I had the x-hole drilled bigger to remove the 1oz of side.  This seemed to take the edge off the flip; great reaction now.

On symmetrical solid balls, I like 5x4 layouts and label shifts.(a stronger version of label leverage)
On symmetrical pearls, I like rev leverage(3x4) and 315 degree layouts.

On asymmetricals, I like all layouts! The balls are just so versatile, you can do all types of things with them.

I have one asymmetrical drilled lefty that I use. I have a S&A drilled almost like a flip/stacked drilling with pin between and under the fingers, mass bias kicked out just a tad. I have an Animal drilled label, for control. I have an original 3D Offset drilled about 1:30,.....but it still flips like crazy.

Can't really say that there's one drilling that I favor. Depends on the conditions, that I'm trying to attack, and the hook-shape that I want.Of course coverstock and core combination play a strong part in that, as well.