What is label? Just because the actual ball label is in the palm doesn't mean the pin would be any where close to the same if the ball had a 1" pin vs a ball with a 4" pin. Very different layouts and possible different reactions. 1" pin is likely below the fingers, 3-4 pin even with or well above the fingers.
The bp software didn't give the options listed at the time I used it but may have changed. You got 2 fingers, a thumb and a x-hole. Im also not sure if it let the x-hole go past 5" Once you go so far then you become counter product on what you remove. It would be nice to see it through the software.
In terms of only a select few I'm not so sure. A p1 x-hole and others lessen the diff of a bowling ball causing it to flare less. No matter how you throw the ball it will have less flare. That is going to reduce the balls reaction.
A p3 and p4 x-hole, plus others such as the Motion hole or adding a x-hole 2-3" down your val all increase the bowling balls int diff and diff. More flare, more fresh oil and possibly more hook. Doesn't matter how you throw it, more flare gives the chance for more hook, and a different ball shape depending on the location.
Location and size does have an effect on the core, flare, and ball reaction.
http://www.youtube.com/watch?v=pPJSmtr75Ts