Generally, the ball will go longer and react stronger down the lane with the CG in the positive quadrant with no balance hole and ending with positive weights.
Generally, placing the CG in the negative quadrant without the need of a balance hole will get the ball into an earlier roll with a smoother reaction down the lane when ending with negative side weight.
Normally a CG out layout will roll sooner with less backend than a layout with the pin out farther than the CG. But, because there are 2 factors working in opposite directions here, A layout that should go longer and snap more (but it has negative weight) vs. a layout that should roll earleir (but is has positive weight) they tend to equal each other out a bit. =:^D