Well the trial version is perfect for just playing around with unless you have one of the 4 balls available on the program. It does show the slight differences in a lot of things and how many things considered a big deal not so much.

Typically I go with 3 layouts, and then just change the surface as needed.  I also don't experiment with exotic layouts since that can be asking for trouble more often than not. 

4x4x2 is the most versatile for me and I have that on at least 1/2 of my arsenal.  The other layouts, such as what I use on my Defiant, Vital Energy or Outlaw are all meant for specific patterns or volume that I face.

Usually, when i get a new ball drilled up, i tend to have a good idea of what type of drilling i am going to do on the ball.. 

And usually it's going to give me a reaction that I can use on a good variety of lane conditions..

here is a example,  I have my Track 916AT drilled pin down, under middle finger ( 5.5 from pap ) and the MB is about 1 inch right of the thumb..  I also have this on my 716C..    this is a good layout for me on a wide variety of patterns because the ball reads the midlane very well..  And the backend reaction isnt wild.   

I also did this drilling on a 706A and 300A to see what it would do for these balls lol... the 706A works good, and actually seems to be a bit earlier than the 716C..  Now on the 300A, i threw this ball for 1 shot and the ball went very straight lol... So I come next week I will see how this ball works going straighter and bumping it off the dry spot on my league night...

Now on most of my other balls, I usually do a pin up over my fingers or pin right under my fingers.. and the MB anywhere from right next to the thumb hole to over at 45degree's..   And with these layouts I get reactions that can cover a wide variety of lane conditions and makes switching out balls pretty easy.