Likely my last post on this topic because I have a partial answer to my topic question:
Had my PSO drill a Pyramid Pathogen Plague Pearl (urethane asymmetric) with a 20x4.5x45 layout. On a medium oily condition, OOB surface and no warmup, this combo out performed my cg-axis Forest-Green Quantum (which I really like). The Quantum had a bigger arc but this urethane ball carried much, much better with a small arc followed by a strong forward roll.
I believe this layout would have been bigger and rounder with a different surface but I don’t care with the way this combo turned out. Will probably drill another asymmetric ball with a small drilling angle layout.