I am getting a DV8 Grudge tomorrow and I need some ideas about laying it out! My ball speed is 17.8 on the monitor. My Rev rate is roughly 400. I was thinking something like 60*4*30, but I'm not an expert on bowling balls.

I would also say a 5 inch pin to pap would work.  This ball is very strong.

I would suggest going to see a certified pro shop technician. These forums are great, but no one knows your bowling style. If you have a favorite layout for strong asymmetrical balls, you could just use something like that. If you have a pro shop you trust, tell them what you are looking for and they should be able to help.