First, set up 2 is, in my humble opinion, a poor set-up for this ball for most bowlers. For most people, it means the ball is trying to roll early and flare early, wasting its energy on the oil rather than waiting til its hits the dry and flips. I think that this just has the ball fighting its own tendencies. Thus, it could be that the ball is unnecessarily expending energy in the front part of the lane and getting into a heavy end over end roll at the back-end (indeed, I would bet on it, I have seen people drill up the Vendetta the same way and complain it doesn't hook). When you combine this tendency with the fact that bowling on a late league you are likely to see carrydown...well, I think the ball set up is wrong.
For me, this ball is actually similar to the Element in the amount of head and midlane oil it will handle. It is not particularly good on carrydown -- it is a pearl after all -- though it is the best of my pearls, but even then it works best when drilled to "go long and flip late". This saves up energy and allows it to go through carrydown more easily than it might otherwise. Frankly, this ball is better on fresh oil with fresh backends, but if you are going to use it late, I wouldn't set it up the way you have.
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"I don't mind if you don't like my manners. I don't like them myself. They're pretty bad. I grieve over them on long winter evenings."