A little insight from my perspective...A little longwinded, I am a shop guy ya know...
All 3 handle medium-heavy oil well. The Mission and Mission $250K (Domination) are a little more forgiving when encountering friction, which was the biggest knock based on our feedback against the 2.0, as it was very very responsive to dry boards. This caused our players to rely on certain layouts and surface adjustments to create the right "look". In a nutshell, when it matched, it was great. When it didnt, it wasnt close. The other Missions offered a little more forgiveness even if not quite prepped to match the pattern perfectly. The Mission $250K is the most angular of the 3 balls in the backend portion of the lane. The Original Mission is sort of the sandwich ball, giving you good clean length through the front (granted you were using it on a pattern with enough volume or your speed matched) and a smooth strong arcing motion down the lane. The Mission 2.0 was similar in length as the other Missions, but due to the high volume of pearl added, it really explodes off the midlane and creates a very "early" look.
To try and simplify where you might apply them to yourself I use this for the guys in the pro shop when they are looking into one of the three. If you like to swing the ball, or are more comfortable seeing stronger motion in the back, drill a $250K. If your used to seeing more even roll across the lane, and sort of play tighter to the oil/dry line, the Original Mission will offer a good choice. For higher speed players, our lower rev rate guys, and the straight down and in, we go with the 2.0. Like I said the 2.0 from our experience has a stronger move off the drier parts of the lane and will open up the midlane really well for those type of players who usually get to the dry a little sooner than the other styles of players we might recommend the other Missions for.
Hope this helps
Strike FX Pro Shops
Cranston, RI
Somerset, MA