The usual way is to clean it every set with some milder, cheap cleaner, then every now and then, using some deep cleaner. Some like a Simple Green mixture for the regular cleaning, then use something like C&D for the deep, once-a-month cleaning.
A combo of Power Wash and C&D is a good routine. PW after each set, then C&D once a month or so, depending on how much bowling you do. If you're a 20+ games a week guy, every other week might be worthwhile.
SH