I never tried a Mission drilled pin up. I can only speak for pin down as that is how I drilled my Mission.
It has a 3 1/8" pin and I drilled it 50* x 4 x 70* with pin under RF and weight hole in the P3 position and it is perfect for my style, speed and revs. This ball is a striking machine and has almost made me forget my Gamebreaker which I really-really loved, but it was 14# and I have switched to 15#, so I put my Gamebreaker in my locker for now. I bowl only on THS and play from along the oil line to just inside the oil line around the 12-13 boards and swinging it out to approx the 7-8 board area. (my specs are in my profile)
My Mission is very versatile and playable on several conditions. I have been able to cut my arsenal to just 2 balls playing THS (Mission and Game On) plus one plastic ball. (Lane 1 Red XXXL).
BTW, the Mission has been Voted the #1 High Performance Ball of the year in the BTM magazine and also was voted the #1 Most Versatile Ball of the year. Results of all balls will be in this month's BTM magizine when it comes out later this month.
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"Whenever I feel the urge to exercise I lie down until the feeling passes away."
Brick