To add to what Bob and 'Bones have said, it can be any number of things. However, it typically doesn't come down to just one thing being different, but a combination of things: Speed, release, extreme line change, and so on. Most bowlers can change any one thing and still be in a relative "comfort zone", but when 2 or 3 or more things need changing all at once, the "A game" goes away pretty quickly.
For me personally, changes in speed and changes to extreme lines do not detract greatly from my game. Yes, there is a speed and line I'd like to use all the time, but I don't lose much in performance outside of them. When you add a third element of change, things start to get tougher pretty quick.
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Kill the back row (or maybe this should read "make your spares, dummy")