High RG makes the ball harder to rev up during the release (but that's rarely a problem), and it bleeds energy off less easily than a low RG piece. This is a great asset when you want the ball to react late and bridge less oily lane regions. So it's good for lighter lane conditions, shorter oil, and can be helpful for low speed players.
The big differential can - depending on the drilling layout - be exploited to get the ball into its roll phase earlier. With the high RG, the ball can push well down the lane, but you might need that re-orientation power from the core to make the ball hook well (read: finish the hooking phase in time when the ball enters the pins). That needs some good timing and an even better ball driller, though.
