My Uranium is drilled 5x4 righthanded, and all I've done is change the grips out so I could throw it lefthanded.  My track is a tad different lefthanded, so it makes the drilling more like 5 1/2x6 or 6 1/2 lefthanded.  The interesting thing is that it's stronger when I use it lefthanded, but should of course be weaker because of the drilling.  I stuck it in the polisher for 2 minutes, and it's still pretty strong.  Just about anything's gonna hook when you throw it 15 mph with 350+ revs on a 35 foot pattern, but when I can still throw it from 3rd arrow out to 3 or 4 at 17 mph with 150-200 revs and it overhooks or crosses over, there's a problem.  The diamond core might have something to do with it, but I'm still a little puzzled as to why it hooks so much more on the left side.  It's not all that much drier on the left side either.
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No, really, I like you.  Now, by all means, feel free to go fornicate yourself with a sharp object.