You're asking a vaild question, but the way you've phrased it puts sort of a biased spin on the answer. You are not taking into account the ball itself and its design parameters: surface, type, and core, as well as oil patterns on which it's used. These, in general, have more of an effect on the ball than the drilling (alhtough core and drilling do go hand in hand).

Also the general classificiations of stroker, tweener, cranker have less of an effect on these drilling, in my opinion, than the other release/delivery characteristics: axis tilt, ball speed, axis of rotation, and ball track/PAP.

The very, very, very general characteristics of those two drillings are
1:30 - more length, later ball reaction, and more backend (more hockey shaped, for the same nowler, for the same ball, for the same oil pattern, etc., etc.)
10:30 - less length, more arc or banana shape, earlier roll and reaction (with same provisos for the 1:30 drilling).

These driling traits can be both advantages or disadvantages, depending on all those other factors which you did not originally take into account: ball's surface, ball's core parameters, bowler's release characteristics, oil pattern, etc.

The important concern here is that all factors must be taken into account before you drill a ball (possibly you knew this and just did not mention it). Either of those drilling or even the middle one: stacked, 4x4, might be the correct one for any bowler, depending on the whole picture.

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"We get old too fast, and too late, smart."