Like a lot of these questions, It depends on what the league rules are. Most leagues define a legal lineup as at least 2 regular members.
Also there is a difference between subs and roster members.
Subs are not regular members, but roster members are.
If your league says regulars and sub count toward a legal lineup then it's legal.
as for them not having bowled before, unless theres a rule about it then it's legal.
some leagues have a rule that say a new person can't start on positions rounds or last two week.