Don't think about it as lefty or righty. Think about it in terms of how far the pin and CG or MB is away from your PAP.
If the lefty in question has, say, the pin over the middle finger and CG kicked out, if your PAP is something like 4 1/2 over, this is nothing more than a 5x6 drill or something like that. Very mild.
Now, if the pin is an inch or two left of the middle -- which for a lefty might be a very strong leverage or pin-axis drilling -- it could place the pin too far away from your PAP and you might end up with inverted flare.
Jess