If you are talking about the different pre cut hada patches for your thumb, there probably is a slight difference in thickness. They appear to be made of different materials, or different densities of a weave of the same material. This produces differences in the feel of how quickly you can get out of the thumb hole. It also stands to reason that different materials, or the same material with a denser weave will have different thicknesses. However, It's definitly not a noticeable difference. It's probably on the order of 1/10 of the difference in thicknesses between pieces of white bowling tape.