For league play on a house pattern, I take 2 balls (plus my spare ball), an IQ Tour solid and either my Phase 3 or my Idol Synergy, just depends which one I feel like using that day.
For my sport shot league I bring 4 (plus my spare ball), I bring the 3 mentioned above plus my only asymmetric, the Physix.
I use the same drilling on every ball and just play around with surface to adjust ball reaction and it seems to work pretty well for me. If I had a 10 ball arsenal I would mix in different layouts to get more separation but what I have works well for me 95% of the time.