Layouts alone are not enough to warrant significant difference in ball reactions. Surface is the BIGGEST factor in ball reaction. When using 2 balls of the same type, having the same layout with different surfaces will give you more versatility than same surface with different layout.
Combining the 2 will give you most bang for buck. If you like a ball but would like it to push further, polish it and drill it for length. I did this with 2 Physix and got exactly what I wanted.