you might get more feedback in the drillings/layout section.
But anyways, just last night I got my The Big One layed out in this manner.
Only difference is that the MB is located closer to the thumb hole on mine.
This ball will do what you wanted to do, though it may be "slightly" snappier with the MB in a stronger position. But playing down and in with very little side turn, the ball gets down the lane (with lots of forward roll) makes a hard arc into pocket at the breakpoint. To slow and it holds line very well, too fast...and it skids past the breakpoint and chops into the 3-6.
Moving way and playing a swing, again the ball clears the head nicely despite the added side turn, and again makes a smooth transition at the breakpoint.
It's definitely a strong layout, but it's a very controlled layout. Most of the time I use layouts that either pin over or pin under the finger holes. I have bad results with pin placements in the 3in area. But this one has worked quite well (with the 2 games I've tried it on)