I can remember Mark Roth's thumb. At times it looked like anything else but a (thumb).
There were times when it got so infected that it had to be lanced.

It just showed that even the very best bowlers are not immune from getting blisters and abrasions. I would think that those of us with far less talent should be expected to  be immune
from what many would consider, a rather normal hazard that soemtimes goes with the game.

 

possible solutions : firmer wrist bend, tighter thumb hole, less bevel, less reverse in the thumb pitch.

Even when I have my thumb snug, I move the tape higher and lower to fine to the fit and speed of release. The higher I put the tape, the longer my thumb will stay in the ball.