Yep, it was the reactive resin ball that made thumb slugs so popular. When reactives first came out, bowlers started finding out that they would hang up in the bare thumbhole of a reactive resin ball, especially if their thumb was in the least bit damp. Urethane slugs give you a cleaner release, plus you can get a more consistent feel from ball to ball. Vinyl slugs and thumb inserts, however, can also give sticking problems if your thumb is damp. So, a lot of bowlers jumped on the urethane slug bandwagon.
One good thing about using a urethane slug is that if something should happen and you don't like the fit, the slug can quickly be drilled out and replaced in a matter of minutes, rather than waiting 24 hours for plug epoxy to cure out.