Flexibility? The thumb points in the same direction the rest of the fingers do, it actually needs to be more flexible to accommodate more REVERSE pitch. I DO have bevel, not much, but enough to take the sharpness off the edge. I bevel for all my customers, but not much to begin with, if they request more, I deal with it. If you do too much, it allows the hand to shift position on the ball and could change an otherwise good fit. If the "fatty skin" or webbing between the thumb and first finger is being irritated by a lack of bevel, that tells me the span is too long AND that the thumb has too much reverse. If the thumb socket is directly over the thumbhole, the span is appropriate, and the hand is in the correct position on the ball, you should not need much bevel, if any. If the webbing is stretched at all, or to the point where rubbing on the front edge of the hole is causing a blister at the base of the thumb, the fit is not correct, or at the very least could be made a lot better. Also keep in mind that the further the thumb is angled away from the palm, the more stretched the webbing becomes. With 0 or forward pitch, the webbing is relaxed.
If bowlers with forward pitches need more bevel, the span is too long or their hand is out of position. There should be no hanging unless there is also gripping. I'm at 0 any direction in my thumb, span is 4 3/8 x 4 7/16, and several years ago it used to be at 1/4 reverse on a slightly longer span. My release is clean every time now that I don't have to grip to hold onto the ball, I rub nowhere, and my thumb doesn't swell anymore, and I have significantly less bevel than I used to. If there's nerve damage, the span is too long or the bowler is gripping. Extra bevel on the front is never a fix, it's a bandaid. It just covers up a poor fit or allows the bowler to continue bad habits.