As long as people understand the purpose of adding any performance based hole, you can make a better ball decision.
The intent of the MOhole is to change the dynamics of the core. The more core mass you can take out, the larger the change is in the core dynamics. So imagine the holes being put in the ball (gripping and MOhole) and see what the difference is. If you think there is a chance the MOhole will not touch the core or take very little out, then it may not be the best choice. But if it seems like the MOhole will take a large chunk of the core mass out, then it may be a good choice. Remember, the more mass you take out, the larger the change in dynamics will be.
Another thing to consider is if the cover is more dominant than the core. A strong cover on a weaker core may not produce as good of results as a weaker cover on a stronger core. This is why medium strength balls have provided significant results.