It depends on whether or not you are a PBA member.
If you are a member, you can bowl in all of the qualifiers, you can make matchplay as often as you are able, and if you win the tournament, you are exempt for the following year.
OTOH, if you are not a PBA member (you're now classified as an "amateur"), you can make it to the round of 64 only once each year, and if you were to win the tournament, you would get to keep the money, but you would not gain an exemption into next year's tour, nor, I believe, are you automatically a PBA member.
That's what I took away from reading the FAQ on pba.com.
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seadrive
Cogito ergo bowl