Hi omega -
It is true that the more you plug and re-drill a ball, the more of its original characteristics will be lost. The reason? Because you are drilling more and more of the surface and core out of a ball and replacing it with plug - which obviously is not going to 100% identical to what was in you ball originally.
That being said, if this is a brand new ball and this is your first plug/redrill to it, I can't imagine that it would affect the ball that much. You should be able to plug/redrill once without affecting the characteristics that much.
Dan