Are the lanes flooded so you never get any reaction? Or are they so dry that your ball dies? If it is a THS, playing up 10 should be fine, assuming you know halfway what you're doing.
I still assume your multi-pin spares are from overworking the ball, though. Generally, when you flag the headpin to the left, your instincts tell you that you have to hook the ball more. So you put a little more hand in it, and next thing you know the ball never moves. The first few things I learned about bowling on carrydown when I first switched to synthetics are a) I hate the spontaneity. b) The harder I try, the lower my scores (again, overworking myself and the bowling ball.) and c) Aside from convincing the staff to give you a freshly ran shot, there is no magical coverstock, core, layout, pitch, or surface preparation that negates or remedies extreme carrydown.
I suggest experimenting during practice. Try a few different things step outside the box a little bit. Try to find something that is a little more effective without sacrificing comfort, and work your way up from there. With confidence, you'll get it.