I bowled no-thumb all of last season, and I drilled quite a few balls for myself in the process. As such, I assume you were referring to the guide provided here:
http://radicalbowling.com/tech-docs/a-radical-look-into-no-thumb-drill-patternsIf that's true, I would advise using the layout you like the best and then adjusting surface to suit your needs. By nature, the Hyroad is pretty clean up front and makes a good move down lane. I believe in letting balls be what they're meant to be, so I would keep the pin in the 2.5-3.5" from PAP region, and then I'd play with surface to get the shape you like.
For me, my Hyroad (a very old and well-used one) was best at 1000 matte. If I smoothed it out or added polish, it was too long for my speed/rev matchup. At 1000, it read the lane and was smooth, a great benchmark ball. But, long story short, I'd put a pretty basic layout on it, one that you've liked in your other no-thumb balls, and then I'd use surface adjustments to fine tune. When adjusting surface, keep in mind that sometimes it takes a lot of experimenting before you find what you like. I probably put 10 different surface adjustments to my Fanatic BTU before I found the surface I liked. Once I found it, it became one of the best no-thumb balls I had in the bag. Just be patient, and I'm sure you'll love your Hyroad!