IMHO if you're going to put the MB to the left of the thumb as a RH bowler you'd be better off just getting a symmetrical cored ball. Putting the MB there on a ball that has a significant amount of asymmetry just takes that MB out of play for the most part.
About the only ball that could have been damaged by drilling into any portion of the core would have been those from Columbia et al that had ceramic nuggets in the core. These were deep enough usually not to cause an issue, unless you had a tendency to drill holes deeper than say 3.5".
Your original question was far to vague to really garner any serious response. In the future I'd suggest that you arm yourself with such information as you PAP, axis tilt and axis rotation to give members here a better idea of who you are as a bowler.
As for "Am I going to get everything out of this ball that I can?" That really depends on how you, as a bowler, execute your release.
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American beer is like making love in a canoe. It's f*cking close to water. - Monty Python
If God had intended us to drink beer, He would have given us stomachs. - David Daye
Edited on 6/10/2005 4:21 AM