Hey Ken,
It depends a little on the reaction you want. You can drill it straight label(i.e.. 4x5) with the cg in palm and pin out next to ring and it'll give you good length with backend vs placing the pin out and cg right of pin (i.e.. 5x3, 4x2) which will make the ball roll sooner and have more of a continuous motion.
It depends on how much speed to revs you have to really tell which layout is more advantageous for you. I'm leaning a little towards the 4x2 because of your description of having high tilt. I'm also assuming you mean high tilt and not high rotation, correct? Let us know and we'll try to help...thanks.
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Rick Leong
Ten Pins Pro Shop
Track Amateur/Pro Shop Staff
Vise Grip Staff